This new discovery suggests that the recurrence of HSV-2 is in the skin and not in the ganglia.
We hope to present the article in it's entirety soon. Genital Shedding of Herpes Simplex Virus Among Symptomatic and Asymptomatic Persons With HSV-2 Infection.
Jia Zhu, Tao Peng, Christine Johnston, Khamsone Phasouk, Angela S. Koelle, Anna Wald, Harlan Robins, and Lawerence Corey Nature 497, 494-497 doi:10.1038/nature12110 () Calcium release within the cells has been shown to be fundamental for the herpes virus. JAMA: The Journal of the American Medical Association, 2011; 305 (14): 1441 DOI: 10.1001/jama.2011.420 A study of patients attending sexual health clinics in Gothenburg, Sweden, found that only four out of ten patients who had genital herpes actually knew that they had contracted the disease.
These scientists found this calcium release occurs because the hsv activates a critical cell signaling molecule called "Akt". HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression. Soc., published online July 5, 2013; doi: 10.1021/ja404008r April, 2013 | The New York Board of Health reported more cases where newborn boys contracted herpes after the Jewish ulta Orthodox practice, "metzitzah b'peh". Also reports found a third of those who did not realise that they had been infected stated typical symptoms at a follow-up visit.
In their study, scientist took human cell cultures and mixed them, for fifteen minutes, with four different drugs which obstruct Akt. All four of the drugs worked notably well to inhibit herpes infection, whereas the cells which were not pretreated with the drugs were easily infected. The FASEB Journal, published online before print March 18, 2013; doi: 10.1096/fj.12-220285 This study shows the herpes internal pressure is so high that it actually blasts its DNA to infect human cells. During the ritual, the mohel, removes the foreskin of the penis, then places his mouth briefly over the wound, sucking a small amount of blood out, to "cleanse" the wound. "The study reinforces our perception that genital herpes is common and that most people carrying it are unaware that they have it," says Matilda Berntsson.
The DNA is so tightly packed, that the force enables the virus to permeate its DNA into the host cell. Two-thirds of boys born in New York City's Hasidic communities are circumcised in the oral suction manner. Researchers, Keith Baratz, MD, and colleagues at the Mayo Clinics in Rochester, MN, and Jacksonville, FL, found that taking oral anti-viral medications lower the risk of recurring eye disease caused by herpes simplex virus.
Hope's research is funded by the NIH and the Center for HIV/AIDS Vaccine Immunology Chicago (March 11, 2008) A CDC study released today estimates that one in four, 26% of young women between the ages of 14 and 19 in the United States are infected with at least one of the most common STDs.
"We have a new understanding of how HIV can invade the female vaginal tract.""Until now, science has really had no idea about the details of how sexual transmission of HIV actually works," Hope added.
It is suggested that antiviral drugs used to treat herpes may help lower or prevent this cognitive deterioration.
PLo S ONE magazine from the Public Library of Science explains the study.
We say one of those ways that needs to be in the equation is that the virus can be transmitted directly through the skin." The next step will be to prove that the virus actually infects the immune cells in the vaginal tract.
"A key experiment in the future is to identify the first cells to get infected in the epithelium, which is not necessarily where people would have looked for them before," Hope said.
"A big mistake in this field is the idea that transmission only takes place one way," Hope said.